Prognostic Impact of Tumor-Infiltrating Immune Cells on Efficacy of Neoadjuvant Chemotherapy in Patients with Advanced or Metastatic Ovarian Cancer: A Retrospective Study.
Med Sci Monit
; 30: e943170, 2024 Jul 17.
Article
em En
| MEDLINE
| ID: mdl-39018268
ABSTRACT
BACKGROUND Tumor-infiltrating immune cells (TIICs) are implicated in the survival of ovarian cancer (OVCA) patients, but their prognostic significance in advanced or metastatic OVCA patients treated with neoadjuvant chemotherapy (NCAT) has not been well documented, particularly in the Chinese population. MATERIAL AND METHODS A total of 31 advanced or metastatic OVCA patients who underwent NACT were included. The density and positive rate of tumor-infiltrating immune cells (TIICs) within cancer cell nests and in cancer stroma were explored. The correlations of pre- or post-NACT TIICs with the efficacy of NACT and the changes in TIIC subpopulation with NACT were examined. RESULTS Compared with patients with partial benefit from NACT, significantly decreased pre-NACT intratumoral CD68âºCD163⺠cells (P=0.0043) and increased pre-NACT intratumoral CD56⺠cells (P=0.038) were observed in patients with benefit. The high level of pre-NACT intratumoral CD68âºCD163â» M1 macrophage (P=0.075) and stromal CD3âºPD-1⺠cells (P=0.085) predicated improved progression-free survival, respectively. Increased post-NACT stromal CD68âºCD163â» M1 macrophage (P=0.01), stromal CD8⺠T cells (P=0.073), and stromal CD8âºPD-1⺠cells (P=0.072) were associated with benefit from NACT. Moreover, NACT increased intratumoral CD3⺠(P=0.031), CD8+ (P=0.031), and CD3âºCD8⺠cells (P=0.031). CONCLUSIONS High intratumoral CD68âºCD163â», intratumoral CD56⺠cells, and stromal CD3âºPD-1⺠cells pre-NACT predicted good prognosis. Intratumoral CD3âº, CD8âº, and CD3âºCD8⺠cells were increased after NACT. Evaluation of immune profiles may help to identify patients who might benefit from NACT and allow us to further stratify advanced or metastatic OVCA patients treated with NACT for disease management.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Linfócitos do Interstício Tumoral
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Terapia Neoadjuvante
Limite:
Adult
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Aged
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Female
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Humans
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Med Sci Monit
Assunto da revista:
MEDICINA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
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UNITED STATES OF AMERICA
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US
/
USA