Predictors of residual disease after breast conservation surgery for ductal carcinoma in situ: A retrospective study.
J Cancer Res Ther
; 20(3): 844-849, 2024 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-39023593
ABSTRACT
BACKGROUND:
Breast-conserving therapy is the standard of care for ductal carcinoma in situ (DCIS). Debate on what constitutes a satisfactory margin persists. This study aimed to identify predictors of residual disease at re-excision.METHODS:
This is a population-based retrospective cohort study of women with DCIS who underwent a lumpectomy between 2007 and 2017 in Manitoba, with close (≤2 mm) or positive margins that led to re-excision.RESULTS:
The DCIS re-excision rate was 29.3% for 1001 patients. 63.2% of patients were found to have residual disease on re-excision. On univariable analysis, the size, margin status, number of positive margins, type of second surgery, and Van Nuys Prognostic Index score were associated with residual disease on re-excision. The size of DCIS and the number of positive margins remained statistically significant on multivariable analysis.CONCLUSIONS:
Re-excision should be rationalized by considering the predictors of residual disease in conjunction with other factors.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Mastectomia Segmentar
/
Carcinoma Intraductal não Infiltrante
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Neoplasia Residual
/
Margens de Excisão
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Cancer Res Ther
Assunto da revista:
NEOPLASIAS
/
TERAPEUTICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Canadá
País de publicação:
IN
/
INDIA
/
ÍNDIA