A NIR-II absorbing conjugated polymer based on tetra-fused isoindigo with ultrahigh photothermal conversion efficiency for cancer therapy.

Wu, Junjie; Rao, Mei; Zhu, Yangwei; Wang, Pai; Chen, Min; Qu, Yijie; Zheng, Xiaohua; Jiang, Yu

Wu, Junjie; Rao, Mei; Zhu, Yangwei; Wang, Pai; Chen, Min; Qu, Yijie; Zheng, Xiaohua; Jiang, Yu.

Afiliação

Wu J; School of Pharmacy, Nantong University, Nantong, Jiangsu, 226019, P. R. China. yujiang@ntu.edu.cn.
Rao M; School of Materials Science and Engineering, Tianjin University, Tianjin 300072, P. R. China.
Zhu Y; School of Pharmacy, Nantong University, Nantong, Jiangsu, 226019, P. R. China. yujiang@ntu.edu.cn.
Wang P; School of Materials Science and Engineering, Tianjin University, Tianjin 300072, P. R. China.
Chen M; School of Pharmacy, Nantong University, Nantong, Jiangsu, 226019, P. R. China. yujiang@ntu.edu.cn.
Qu Y; School of Pharmacy, Nantong University, Nantong, Jiangsu, 226019, P. R. China. yujiang@ntu.edu.cn.
Zheng X; School of Pharmacy, Nantong University, Nantong, Jiangsu, 226019, P. R. China. yujiang@ntu.edu.cn.
Jiang Y; School of Pharmacy, Nantong University, Nantong, Jiangsu, 226019, P. R. China. yujiang@ntu.edu.cn.

Chem Commun (Camb) ; 60(64): 8427-8430, 2024 Aug 06.

Article em En | MEDLINE | ID: mdl-39034822

ABSTRACT

ABSTRACT

A conjugated polymer, P4TTD-DPP, based on tetra-fused isoindigo-alt-diketopyrrolopyrrole, has been synthesized as a photothermal therapeutic nanotransducer within the near-infrared-II (NIR-II) window. P4TTD-DPP exhibits a notable mass extinction coefficient of 62.8 L g-1 cm-1 at 1064 nm. Additionally, P4TTD-DPP nanoparticles demonstrate remarkable photothermal conversion efficiency of 91.5% at 1064 nm and exhibit excellent anticancer efficacy under photothermal conditions.

Assuntos

Antineoplásicos; Raios Infravermelhos; Polímeros; Polímeros/química; Polímeros/farmacologia; Polímeros/síntese química; Humanos; Antineoplásicos/química; Antineoplásicos/farmacologia; Antineoplásicos/síntese química; Sobrevivência Celular/efeitos dos fármacos; Nanopartículas/química; Indóis/química; Indóis/farmacologia; Terapia Fototérmica; Linhagem Celular Tumoral; Ensaios de Seleção de Medicamentos Antitumorais; Pirróis/química; Pirróis/farmacologia; Fototerapia; Camundongos; Estrutura Molecular; Animais

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polímeros / Raios Infravermelhos / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de publicação: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM

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