Effect of cisplatin on the oxidative metabolism of polymorphonuclear leukocytes in cancer patients.
Tumori
; 70(3): 227-9, 1984 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-6330946
ABSTRACT
Peripheral blood polymorphonuclear leukocytes of patients with ovarian or uterine-cervix carcinoma were studied during cisplatin chemotherapy for phagocytic oxidative metabolism. In particular, superoxide production by these leukocytes after stimulation with opsonized Zymosan particles was determined. The basal value of oxidative metabolism of leukocytes from neoplastic patients was lower than in normals. Superoxide production decreased after each dose administration, but returned to normal at the end of the entire chemotherapeutic treatment. It is suggested that cisplatin treatment, despite a short-lived depression of oxidative metabolism in polymorphonuclear cells, improves this function, most probably by interfering with neoplastic growth.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Consumo de Oxigênio
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Neoplasias do Colo do Útero
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Cisplatino
/
Neutrófilos
Limite:
Female
/
Humans
Idioma:
En
Revista:
Tumori
Ano de publicação:
1984
Tipo de documento:
Article
País de publicação:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
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US
/
USA