Effect of testosterone on the female hamster Harderian gland pigmentation and ultrastructure.
Cell Tissue Res
; 207(3): 511-7, 1980.
Article
em En
| MEDLINE
| ID: mdl-7397759
ABSTRACT
Distinct differences occur in the pigmentation and ultrastructural features of the Harderian glands in male and female hamsters. The results of a study on the effect of testosterone on the fine structure of the female Harderian glands are presented here. Glands from three groups of hamsters were examined at intervals up to 49 days (1) testosterone injected, receiving 2 mg testosterone propionate in 0.1 ml sesame oil per day; (2) sham-injected, receiving 0.1 ml sesame oil per day; (3) untreated controls. Testosterone injections caused a reduction in the number of dark-brown pigment granules in the acinar cells starting on the 6th day, whereas clusters of tubules, typical of adult male glands, appeared on the 4th day and increased in number thereafter. Lamellar structures, normally present in the female gland, decreased in testosterone treated specimens. These changes reversed after cessation of testosterone treatment. It is concluded that exogenous testosterone administered to female hamsters modifies the pigmentation and ultrastructure of their Harderian glands towards the male type and that this is a reversable phenomenon. There also appears to be an inverse relationship between the presence of tubular clusters in the acinar cells, and the degree of pigmentation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testosterona
/
Glândula de Harder
/
Aparelho Lacrimal
Limite:
Animals
Idioma:
En
Revista:
Cell Tissue Res
Ano de publicação:
1980
Tipo de documento:
Article
País de publicação:
ALEMANHA
/
ALEMANIA
/
DE
/
DEUSTCHLAND
/
GERMANY