Vaccination of cattle with outer membrane protein-enriched fractions of Pasteurella haemolytica and resistance against experimental challenge exposure.
Am J Vet Res
; 56(7): 875-9, 1995 Jul.
Article
em En
| MEDLINE
| ID: mdl-7574154
ABSTRACT
Administration of an N-lauroylsarcosine-derived outer membrane protein fraction of Pasteurella haemolytica A1 (SCI-1) induced a protective response in calves against intrathoracic challenge exposure with the homologous serovar. Outer membrane proteins from heterologous serovars, A6 and A9, induced partial protection that was associated with their respective similarities to serovar A1 in outer membrane protein profiles derived by use of sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Calves vaccinated with SCI preparations did not have detectable neutralizing antibody to P haemolytica A1 leukotoxin. Antibodies to whole-cell antigens, carbohydrate-protein subunit antigen, and SCI-1 were associated with resistance, which indicates that protein antigens shared among cell surface, carbohydrate-protein subunit, and SCI preparations are immunogenic and enhance resistance to experimental challenge exposure.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Pasteurella
/
Proteínas da Membrana Bacteriana Externa
/
Vacinas Bacterianas
/
Mannheimia haemolytica
Limite:
Animals
Idioma:
En
Revista:
Am J Vet Res
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos