An acquired cryoglobulinemia which inhibits fibrin polymerization in a patient with IgG kappa myeloma.
Haemostasis
; 23(1): 69-76, 1993.
Article
em En
| MEDLINE
| ID: mdl-8477911
ABSTRACT
A 58-year-old man with multiple myeloma and paraproteinemia (IgG kappa) acquired cryoglobulinemia 2 years after the initial diagnosis of the disease. This cryoglobulin interfered specifically with fibrin aggregation. The patient's fibrinogen was functionally normal; however, clotting times (thrombin clotting time, reptilase clotting time) were prolonged in the untreated plasma and in the supernatant after removal of the cryoglobulins. Untreated patient's serum, and even more pronounced, the cryoprecipitate inhibited the association of fibrin monomers obtained from healthy controls. The inhibitory activity on fibrin aggregation diminished upon treatment-induced reduction of plasma protein levels.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos da Coagulação Sanguínea
/
Proteínas do Mieloma
/
Fibrina
/
Cadeias kappa de Imunoglobulina
/
Crioglobulinemia
/
Mieloma Múltiplo
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Haemostasis
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Áustria