Your browser doesn't support javascript.
loading
Mapping of chromosomal gains and losses in primitive neuroectodermal tumors by comparative genomic hybridization.
Schütz, B R; Scheurlen, W; Krauss, J; du Manoir, S; Joos, S; Bentz, M; Lichter, P.
Afiliação
  • Schütz BR; Deutsches Krebsforschungszentrum, Abteilung Organisation komplexer Genome, Heidelberg, Germany.
Genes Chromosomes Cancer ; 16(3): 196-203, 1996 Jul.
Article em En | MEDLINE | ID: mdl-8814453
ABSTRACT
A series of 18 primitive neuroectodermal tumors (PNETs), the most common malignant central nervous system tumors of childhood, were analyzed with the recently developed approach of comparative genomic hybridization (CGH). In five cases, in which only small amounts of DNA were available, universal polymerase chain reaction was successfully applied to generate adequate probe material. In 15 tumors, chromosomal imbalances were elicited, most frequently involving chromosome 17 (loss of 17p and gain of 17q). Further recurrent imbalances included gains of the distal regions of 4p, 5p, 5q, 7q, 8q, and 9p. High-level amplifications were found on 2p24 (one case) and 8q24 (three cases), suggesting involvement of the protooncogenes MYCN and MYC, respectively. In one of these cases, Southern blot analysis could be performed, proving high-copy-number amplification of MYC. Interestingly, none of the three patients with high-copy-number amplifications of MYC responded to therapy.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tumores Neuroectodérmicos Primitivos / Aneuploidia Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Genes Chromosomes Cancer Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Alemanha País de publicação: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tumores Neuroectodérmicos Primitivos / Aneuploidia Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Genes Chromosomes Cancer Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Alemanha País de publicação: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA