DNA interaction and electrochemical properties of bis-1-aminomethylnaphthalenes and related compounds. A correlation with their antineoplastic activity.
Boll Chim Farm
; 135(6): 374-7, 1996 Jun.
Article
em En
| MEDLINE
| ID: mdl-8942064
ABSTRACT
Bis-1-aminomethylnaphthalenes constitute a new type of molecule with antineoplastic activity. As a first approach to determine the action mechanism, the interaction degree of these compounds and some less active analogous, with calf thymus DNA, by UV spectrophotometry, and the redox performance by cyclic voltammetry was correlated with their activity on neoplastic cell lines. It suggests that the most active members interact closely with DNA but do not show any redox process at biological potentials.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Naftalenos
/
Antineoplásicos
Idioma:
En
Revista:
Boll Chim Farm
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
IT
/
ITALIA
/
ITALY
/
ITÁLIA