[Combination therapy of daily intramuscular injection of interferon-alpha and oral administration of fluorouracil for advanced renal cell carcinoma].
Nihon Hinyokika Gakkai Zasshi
; 89(3): 421-5, 1998 Mar.
Article
em Ja
| MEDLINE
| ID: mdl-9577557
ABSTRACT
BACKGROUND:
To achieve optimum drug delivery of Interferon-alpha in treatment of renal cell carcinoma, a regimen consisting of its daily intramuscular administration, in combination with oral fluorouracil, was designed and carried out. Its efficacy is examined retrospectively.METHODS:
In our department 7 patients with disseminated renal cell carcinoma were treated with daily intramuscular injection of interferon-alpha (3 x 10(6) IU) and daily oral administration of fluorouracil. All patient was nehprectomized before initiation of the regimen.RESULTS:
Two patients achieved complete, and three patients achieved partial response radiographically (Overall response rate 71%). Metastatic sites of responders were lung (4) and pleura (2). The time required until response was 3.9 (median 5.4) months. In two responders, new lesions appeared in other organs despite durable response in initial pulmonary metastatic sites. There were two no-responders, one patient is alive with stable disease and the other patient died for progression of the disease. In all, two patients died of disease, one died for other cause, one surviving without evidence of disease, and three are surviving with disease. No significant side effect was noted in these seven patients.CONCLUSIONS:
This regimen can be carried out on outpatient basis and considerable response can be expected for pulmonary and pleural lesions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Renais
/
Protocolos de Quimioterapia Combinada Antineoplásica
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Neoplasias Renais
Limite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
Ja
Revista:
Nihon Hinyokika Gakkai Zasshi
Ano de publicação:
1998
Tipo de documento:
Article
País de publicação:
JAPAN
/
JAPON
/
JAPÃO
/
JP