Antiischemic effect of ZK-118.182 in rabbits: a comparative study with iloprost.
Methods Find Exp Clin Pharmacol
; 20(4): 339-42, 1998 May.
Article
em En
| MEDLINE
| ID: mdl-9658384
ABSTRACT
The effects of ZK-118.182, a stable analogue of PGD2, were evaluated in an endothelin-1-induced cerebral ischemia rabbit model. Ischemia was induced by endothelin-1 injection (0.25 ng bolus) into subcavian artery and ischemic changes were assessed histologically by the number of ischemic neurons in the brain stem. ZK-118.182 (2 micrograms/kg, bolus into subclavian artery) reduced the number of ischemic neurons when injected 20 min after endothelin-1 injection, Iloprost, a stable analogue of PGI2, was also effective in reducing the number of ischemic neurons in a dose of 0.5 microgram/kg (bolus into subclavian artery). The results suggested that ZK-118.182 has a potent antiischemic effect which is comparable to that of iloprost in rabbits.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Agregação Plaquetária
/
Dinoprosta
/
Isquemia Encefálica
/
Iloprosta
Limite:
Animals
Idioma:
En
Revista:
Methods Find Exp Clin Pharmacol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Turquia