Cobalamin-dependent methionine synthase and serine hydroxymethyltransferase: targets for chemotherapeutic intervention?
Adv Enzyme Regul
; 38: 377-92, 1998.
Article
em En
| MEDLINE
| ID: mdl-9762364
ABSTRACT
Chemotherapeutic drugs targeted at folate-dependent reactions have typically been directed at a limited number of target enzymes dihydrofolate reductase, thymidylate synthase, and GAR and AICAR transformylase. This review discusses two other potential targets for chemotherapeutic inhibition cobalamin-dependent methionine synthase and serine hydroxymethyltransferase. Brief reviews of the catalytic properties of these two enzymes are presented, and possible strategies for chemotherapeutic intervention are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicina Hidroximetiltransferase
/
5-Metiltetra-Hidrofolato-Homocisteína S-Metiltransferase
/
Tratamento Farmacológico
/
Inibidores Enzimáticos
Limite:
Humans
Idioma:
En
Revista:
Adv Enzyme Regul
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
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SCOTLAND
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UK
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UNITED KINGDOM