Treatment of staphylococcal septic arthritis in rabbits by systemic antibiotics and intra-articular corticosteroids.
Ann Rheum Dis
; 57(11): 687-90, 1998 Nov.
Article
em En
| MEDLINE
| ID: mdl-9924212
ABSTRACT
OBJECTIVE:
To assess the effect of intra-articular corticosteroids added to systemic antibiotics in experimental septic arthritis.METHODS:
Rabbits were injected intra-articularly by Staphylococcus epidermidis. Rabbits received no additional treatment and served as control (group 1), were treated with systemic antibiotics (group 2), or treated with systemic antibiotics and intra-articular corticosteroids (group 3). After 15 days animals were killed and joint histopathological-histochemical parameters were assessed.RESULTS:
All rabbits survived the experiment. The treated groups (2-3) had lower histological-histochemical scores in comparison with the untreated group (1). Group 3 had significantly lower scores in joint sections in comparison with group 2 (mean (SD) 6.5 (1.4) v 4.0 (1.0), p = 0.001 and 7.4 (2.6) v 4.2 (2.2), p = 0.01), because of lower damage expressed in clustering of chondrocytes, pannus formation, proteoglycan depletion, and synovitis.CONCLUSION:
Addition of local corticosteroids to systemic antibiotics in septic arthritis seems to be harmless, and improves joint histological-histochemical parameters in this experimental setting.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Experimental
/
Infecções Estafilocócicas
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Staphylococcus epidermidis
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Artrite Infecciosa
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Cefalosporinas
/
Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Revista:
Ann Rheum Dis
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Israel
País de publicação:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM