Comparison of homozygous sickle cell disease in Northern Greece
Lancet
; 335(8690): 637-40, Mar. 17, 1990.
Artigo
em Inglês
| MedCarib
| ID: med-10011
Biblioteca responsável:
JM3.1
Localização: JM3.1; R31.L3
ABSTRACT
The clinical and hematological features of homozygous sickle cell (SS) disease were compared in 30 Greek and 310 Jamaican patients. Deletional O-thallassaemia, which modifies SS disease, is rare among Greek patients, so only Jamaican patients with four O-globin genes were included in the control group. Greek patients had higher total haemoglobin concentration and red cell counts, and lower mean cell haemoglobin concentration (MCHC) and reticulocyte counts. They also had a more normal body build and more adults had persistent splenomegaly. Fewer had a history of leg ulceration or priapism but more reported acute chest syndrome. The comparitively mild disease in Greek patients is consistent with less haemolysis and sickling and therefore less bone marrow expansion. In the absence of amelioriating factors such as high HbF concentration or O-thalassaemia, these findings may be explained by the low MCHC. (AU)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Homozigoto
/
Anemia Falciforme
Tipo de estudo:
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Criança
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Caribe Inglês
/
Europa
/
Jamaica
Idioma:
Inglês
Revista:
Lancet
Ano de publicação:
1990
Tipo de documento:
Artigo