Intrathecal synthesis of antibodies to human T lymphotropic virus type I and the presence of IgG oligoclonal bands in the cerebrospinal fluid of patients with endemic tropical spastic paraparesis
J Infect Dis
; 157(6): 1226-34, June 1988.
Artigo
em Inglês
| MedCarib
| ID: med-10056
Biblioteca responsável:
JM3.1
Localização: JM3.1; R11.J71
ABSTRACT
Tropical spastic paraparesis (TSP), a neuromyelopathy predominantly involving the pyramidal tract and commonly observed in tropical and equatorial areas, was recently found to be associated with human T lymphotropic virus type I (HTLV-I). We investigated sera and cerebrospinal fluid (CSF) from 19 patients with TSP who were from the Caribbean area, French Guiana, and Africa. Our results showed an elevated intra-blood-brain barrier IgG synthesis rate and an elevated IgG index, with an increased HTLV-I antibody-to-albumin ratio and the presence of CSF oligoclonal bands in the majority of the patients. These data, in association with similar HTLV-I antibody patterns between patients with TSP who were from these three regions, strenghten the probable etiologic role of HTLV-I in the pathogenesis of such chronic neuromyelopathies. (AU)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Paralisia
/
Doenças da Medula Espinal
/
Imunoglobulina G
/
Infecções por Deltaretrovirus
/
Deltaretrovirus
/
Anticorpos Antivirais
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
África
/
América do Sul
/
Caribe
/
Guiana Francesa
Idioma:
Inglês
Revista:
J Infect Dis
Ano de publicação:
1988
Tipo de documento:
Artigo