Human T lymphotropic virus type I antibody patterns: evidence of difference by age and risk group
J infect dis
; 158(6): 1235-44, Dec. 1988.
Artigo
em Inglês
| MedCarib
| ID: med-10057
Biblioteca responsável:
JM3.1
Localização: JM3.1; R11.J71
ABSTRACT
Detection of human T lymphotropic virus type I (HTLV-I) antibody was assessed on 368 sera from subjects with different clinical features and from different parts of the world. Enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay for purified p24 antibodies (p24-RIA) used as screening tests agreed in 88.7 percent of the sera. The results from 247 selected sera were compared with western blot (WB). WB was reactive in sera five to 25 times more dilute than the last positive ELISA or p24-RIA, but different WB batches varied in sensitivity. ELISA was more sensitive than p24-RIA, and p24-RIA was more specific than ELISA. Indeterminate WB interpretations were common (25.5 percent). Most seropositive intravenous drug abusers had unusually strong p24 bands by WB. Among healthy individuals, positive WB reactivity increased with age, whereas indeterminate reactivity declined (P=.034). Thus more sensitive and -specific HTLV-I antibody tests are needed. (AU)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Anticorpos Anti-HTLV-I
/
Infecções por HTLV-I
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Idoso
/
Idoso, 80 anos ou mais
/
Criança
/
Criança, pré-escolar
/
Humanos
País/Região como assunto:
África
/
América Central
/
América do Norte
/
Ásia
/
Caribe Inglês
/
Jamaica
/
Panamá
Idioma:
Inglês
Revista:
J infect dis
Ano de publicação:
1988
Tipo de documento:
Artigo