Counteraction of glucocorticoid - induced hyperglycaemia by hypoglycin

ABSTRACT

Hypoglycin, B-(methylenecyclopropyl) alanine), administered to starved rats pretreated with corticosterone, caused within 6 hr. a marked decline in blood sugar levels. The findings are evidence that the hypoglycaemic agent imposed a restriction on the rate of gluconeogenesis, against which the multiple actions of the hormone were effective. This conclusion emphasizes the crucial nature of the inhibition which hypoglycin produces in the metabolic sequence of gluconeogenesis (AU)