Effects of reserpine, tranylcypromine, haloperidol and Fla-63 on physostigmine - Induced hyperactivity in rats

ABSTRACT

The effects of bis (4-methyl-l-homopiperazinyltio - carbonyl) disulphide (FLA-63), haloperidol, reserpine and tranylcypromine on physostigmine-inducedhyperactivity in rats were studied using jiggle platforms to measure motor activity levels. Haloperidol (0.025 mg/kg). On the other hand FLA-63 (2.5 mg/kg) and tranylcypromine (20 mg/kg) attenuated the effect of physostigmine during the first thirty minutes of testing and caused a potentiation during the next thirty minutes. All drugs were administered intraperitoneally. These results support the hypothesis of an interaction between the cholinergic and catecholminergic systems in the central nervous system (AU)