Demonstration of anticonvulsant properties of an aqueous extract of Spirit Weed (Eryngium foetifdum L.)
West Indian med. j
; 35(2): 121-5, June 1986.
Artigo
em Inglês
| MedCarib
| ID: med-11591
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
Rats were used to investigate the anticonvulsant potential of two aqueous extracts of Spirit Weed. In this investigation, convulsions were induced by picrotoxin (4.5 mg/kg, i.p.) and these convulsions were consistently abolished by the intraperitioneal (i.p.) infections of aliquots (3ml each) of a steam distillate extract of Spirit Weed. However, those rats which served as controls as well as those which were injected with aliquots (3 ml each) of the boiled aqueous decoction of Spirit Weed, died after 2 hours of convulsions. Also, the steam distillate extract of Spirit Weed delayed (by 12 + 3 minutes) the onset of convulsions when it was given before picrotoxin (4.5 mg/kg, i.p.). Additionally, the steam distillate extract of Spirit Weed mimicked the anticonvulsant effect of phenobarbitone in the same group of rats. Moreover, the steam distillate extract of Spirit Weed did not produce generalized central nervous sustem depression in conscious rats. Therefore, it is concluded that an ingredient in the steam distillate extract of Spirit Weed has anticonvulsant properties which may be useful in the treatment of some forms of epilepsy. This requires further investigation (AU)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Plantas Medicinais
/
Convulsões
/
Extratos Vegetais
/
Anticonvulsivantes
Limite:
Animais
Idioma:
Inglês
Revista:
West Indian med. j
Ano de publicação:
1986
Tipo de documento:
Artigo