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Reduction by morphine of human prosprandial insulin release is secondary to inhibition of gastrointestinal motility
Diabetes;35(3): 324-7, Mar. 1986.
Preprint em Inglês | MedCarib | ID: med-14078
Biblioteca responsável: JM3.1
Localização: JM3.1; RC660.A1D5
ABSTRACT
The effect of morphine (0.1 mg/kg) on insulin secretion stimulated by oral, intraduodenal, or intravenous administration of glucose was studied in seven healthy volunteers. When glucose was given intravenously, morphine had no effect on plasma glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP), or pancreatic glucagon. Following oral glucose, morphine slowed gastric emptying and reduced plasma concentrations of glucose, insulin, and GIP. During intraduodenal infusion of glucose, insulin concentrations of plasma were also decreased by morphine, an effect best explained by decreased small intestinal transit with delayed absorption of glucose and delayed release of GIP. We conclude that clinically relevant doses of morphine have no direct effect on insulin secretion and that the changes observed were secondary to slowed gastric emptying and small intestinal transit (AU)
Assuntos
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Coleções: Bases de dados internacionais Contexto em Saúde: ODS3 - Meta 3.5 Prevenção e tratamento do consumo de substâncias psicoativas Problema de saúde: Abuso de Opioides Base de dados: MedCarib Assunto principal: Motilidade Gastrointestinal / Insulina / Morfina Limite: Adolescente / Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Diabetes Ano de publicação: 1986 Tipo de documento: Preprint
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Coleções: Bases de dados internacionais Contexto em Saúde: ODS3 - Meta 3.5 Prevenção e tratamento do consumo de substâncias psicoativas Problema de saúde: Abuso de Opioides Base de dados: MedCarib Assunto principal: Motilidade Gastrointestinal / Insulina / Morfina Limite: Adolescente / Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Diabetes Ano de publicação: 1986 Tipo de documento: Preprint
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