Activation of the alternative pathway of human complement by haemoglobin
Clin Exp Immunol
; 36(1): 140-4, Apr. 1979.
Artigo
em Inglês
| MedCarib
| ID: med-14374
Biblioteca responsável:
JM3.1
Localização: JM3.1; RC583.C5
ABSTRACT
Haemoglobin solutions (concentration >1.5mg/ml), prepared from lysates of erythrocytes from a normal subject and from a patient with sickle cell anaemia, caused factor B and C3 cleavage and loss of haemolytic activity of factor B when incubated with fresh autologous serum. Under the same experimental conditions, preparations of erythrocyte stroma or of buffy coat lysates did not produce factor B and C3 cleavage. This reaction required Mg++ but not Clq or C4, indicating that the alternative complement pathway was activated (Summary)
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Base de dados:
MedCarib
Assunto principal:
Hemoglobinas
/
Ativação do Complemento
/
Via Alternativa do Complemento
Limite:
Humanos
Idioma:
Inglês
Revista:
Clin Exp Immunol
Ano de publicação:
1979
Tipo de documento:
Artigo