The human type-C retrovirus, in Blacks from the Caribbean region, and relationship to adult T-cell leukemia/lymphoma
Int J Cancer
; 30(3): 257-64, Sept. 15 1982.
Artigo
em Inglês
| MedCarib
| ID: med-14448
Biblioteca responsável:
JM3.1
Localização: JM3.1; RC261.A34
ABSTRACT
Type-C RNA tumour viruses have been implicated in the etiology of naturally occurring leukemias and lymphomas of animals. Human T-cell leukimia/lymphoma virus (HTLV) is the first human virus of this class consistently identified in association with a specific type of human leukemia/lymphoma. The isolation of HTLV was made possible by the ability to grow mature T-cell in tissue culture usually with T-cell growth factor (TCGF). We now report a cluster usually with T-cell leukemia/lymphoma among Blacks from the Caribbean in which all eight cases are positive for HLV virus and/or antibody. These patients have diseases that appears indistinguisable from Japanese adult T-cell leukemia/lymphoma which, as we have also reported, is associated with HTLV in over 90 percent of cases. The finding of HTLV antibodies in some of the normal population in the Caribbean and Japan, and the clustering of a specific form of T-cell leukemia/lyphoma in these virus-endemic areas, suggest that HTLV infection may be associated with the occurrence of a distinctive clinico-pathologic entity (Summary)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Retroviridae
/
Infecções Tumorais por Vírus
/
Leucemia
/
Linfoma
Tipo de estudo:
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Caribe
Idioma:
Inglês
Revista:
Int J Cancer
Ano de publicação:
1982
Tipo de documento:
Artigo