Haemoglobin F Jamaica (Alpha-2 gamma-2 61 Lys --> Glu; 136 Ala)
Br J Haematol
; 18(3): 369-75, March 1970.
Artigo
em Inglês
| MedCarib
| ID: med-14572
Biblioteca responsável:
JM3.1
Localização: JM3.1; RB145.A1B7
ABSTRACT
Two siblings of mixed Negro, East Indian and Causacian parentage showed an abnormal haemoglobin component in infancy which had electrophoretic characteristics similar to Hb F Roma (Silvestroni & Bianco, 1963). The amino-acid substitution responsible for the peculiar electrophoretic mobility was found to be in the gamma polypeptide chain (gamma-61(E5)Lys-->Glu). The finding of an alanyl residue at position of 136 of the gamma-chain of the abnormal component in the first born of these infants was repeated in the abnormal gamma-chain of the second infant. No functional abnormalities were found to be associated with this abnormal haemoglobin, which is designated Hb F Jamaica (Summary)
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Base de dados:
MedCarib
Assunto principal:
Hemoglobina Fetal
/
Hemoglobinas Anormais
Limite:
Adulto
/
Feminino
/
Humanos
/
Lactente
/
Masculino
/
Recém-Nascido
País/Região como assunto:
Caribe Inglês
/
Jamaica
Idioma:
Inglês
Revista:
Br J Haematol
Ano de publicação:
1970
Tipo de documento:
Artigo