A genetic marker for elevated levels of haemoglobin F in homozygous sickle cell disease
Br J Haematol
; 60(2): 261-8, June 1985.
Artigo
em Inglês
| MedCarib
| ID: med-14710
Biblioteca responsável:
JM3.1
Localização: JM3.1; RB145.A1B7
ABSTRACT
Ten patients with sickle cell (SS) disease from a Jamaican family were found to have unusually high levels of haemoglobin F for this population. Each of them has inherited one sickle cell gene on a chromosome characterized by an arrangement of restriction fragment length polymorphisms (haplotype) which is very rare in the Jamaican population. Genetic analysis of the family suggests that there is a determinant linked to the á-globin gene cluster, charaterized by this haplotype, which is responsible for increased haemoglobin F production in response to anaemia. Interestingly this particular haplotype appears to be common in patients with SS disease in eastern Saudi Arabia in whom a high level of haemoglobin F is the rule rather than the exception. Hence it is possible that this haplotype (++-++) acts as a genetic marker for elevated levels of haemoglobin F in sickle cell disease (AU)
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Base de dados:
MedCarib
Assunto principal:
Traço Falciforme
/
Hemoglobina Fetal
/
Marcadores Genéticos
/
Anemia Falciforme
Limite:
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
/
Caribe Inglês
/
Jamaica
Idioma:
Inglês
Revista:
Br J Haematol
Ano de publicação:
1985
Tipo de documento:
Artigo