Effect of alpha thalassaemia on the rheology of homozygous sickle cell disease
Br J Haematol
; 55(3): 479-86, Nov. 1983.
Artigo
em Inglês
| MedCarib
| ID: med-14722
Biblioteca responsável:
JM3.1
Localização: JM3.1; RB45.A1B7
ABSTRACT
A study of rheological determinants (plasma viscosity, whole-blood viscosity, and erythrocyte deformability) was made in 24 matched pairs of patients with homozygous sickle cell disease, with and without homozygous x-thalassaemia. Patients with coexisting x-thalassaemia showed a significant increase in erythrocyte deformability measured as filtration of washed erythrocytes through 5 um diameter pores and also as viscosity of whole blood at high shear rate (230s-1) and standard haematocrit (0.45). This rheological advantage may explain the beneficial effect of x-thalassaemia 2 on haematological parameters and clinical events in homozygous sickle cell disease (AU)
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Base de dados:
MedCarib
Assunto principal:
Talassemia
/
Doença da Hemoglobina SC
/
Anemia Falciforme
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Br J Haematol
Ano de publicação:
1983
Tipo de documento:
Artigo