Quantitative estimation of free and bound serum aldehyde

ABSTRACT

On heating human serum with As2O3 in the presence of methanol, the level of aldehyde is increased. The increase, expressed as a percentage of the total aldehyde content, is referred to as the bound aldehyde. In the sera of patients with early malignancy, the value of bound aldehyde is found to be significantly lower than that of normal sera, but as metastases occur, it rises above the normal value. In the sera of patients with malignancy, but who responded to treatment, the value for bound aldehyde is similar to that found in the sera of patients with non-malignant disease (AU)