Detection of alpha thalassaemia in Negro infants
Br J Haematol
; 46(1): 39-46, Sept. 1980.
Artigo
em Inglês
| MedCarib
| ID: med-14809
Biblioteca responsável:
JM3.1
Localização: JM3.1; RB145.A1B7
ABSTRACT
A prospective study of 2191 Negro infants in Jamaica showed that approximately 7 percent of them had detectable levels of Hb Bart's (Y4) in the neonatal period. The red cell indices, globin chain biosynthesis and restriction endonuclease mapping of DNA from these infants were used to determine the significance of Hb Bart's at birth. The results indicate that the genotypes OO/OO, - O/OO and - O/-O are associated with 0 percent, 0.1-2 percent, and greater than 2 percent Hb Bart's respectively. Although trace amounts of Hb Bart's may be associated with the genotype - O/OO this is not always the case and therefore haemoglobin analysis in the neonatal period cannot be used to diagnose this genotype with any certainty (AU)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Talassemia
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Fatores de risco
Limite:
Humanos
/
Lactente
/
Recém-Nascido
País/Região como assunto:
Caribe Inglês
/
Jamaica
Idioma:
Inglês
Revista:
Br J Haematol
Ano de publicação:
1980
Tipo de documento:
Artigo