The use of griseofulvin in the treatment of the dermatomycoses

ABSTRACT

A brief review of the history leading from research begun in 1939 to Gentles' successful cure of guinea pigs infected with fungi in 1958 and the first clinical use of griseofulvin by Williams, Blank and Riehl (1958), is given. The use and misuse of griseofulvin is discussed. Dosage, duration and control of treatment are described and the rare and never dangerous side effects are mentioned. An account of 84 personal cases of dermatomycosis treated with griseofulvin is presented. This includes a report on a case of chromomycosis which was cured by combined treatment with vitamin D2 and griseofulvin (AU)