Haemorrhage - a complication in the treatment of chorion carcinoma by chemotherapy

ABSTRACT

Three recent cases of chorion carcinoma have been treated with methotrexate and 6 mercaptopurine. One patient fell pregnant following therapy and was subsequently delivered, after an uneventful ante-natal course, of a normal infant. The main complication during the therapy was haemorrhage from the necrosing vaginal secondaries, which was felt to be the direct effect of the drugs. The bleeding was best controlled by bilateral internal iliac ligation, prior to chemotherapy. (Summary)