Mesolimbic deficits exacerbate amphetamine treatment: clinical implications for drug abusers
West Indian med. j
; 41(3): 111-5, Sept. 1992.
Artigo
em Inglês
| MedCarib
| ID: med-15670
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
Amphetamine, a common drug used by abusers, is able to produce a schizophreniform psychosis in man. The experiment reported here examined amphetamine in relation to its role in the nucleus accumbens septi (NAS) and the globus pallidus. The effects produced by apomorphine, a direct dopamine (DA) agonist, were compared with those of amphetamine, a known indirect DA agonist. The data revealed that amphetamine in NAS-lesioned animals produced very active stereotypy which intensified with time. This effect was blocked by pallidal lesioning. Apomorphine in pallidectomised rats produced persistent stereotypy, but of diminished intensity. The results are discussed in terms of the mediating roles of the NAS and globus pallidus on behavioural sequelae. (AU)
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Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.5 Prevenção e tratamento do consumo de substâncias psicoativas
Problema de saúde:
Meta 3.5 Prevenção e tratamento do consumo de substâncias psicoativas
/
Outros Transtornos Relacionados ao Uso de Substâncias Psicoativas
Base de dados:
MedCarib
Assunto principal:
Globo Pálido
/
Anfetaminas
/
Núcleo Accumbens
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
West Indian med. j
Ano de publicação:
1992
Tipo de documento:
Artigo