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Evaluation of oestrogen, progesterone receptors and c-erb-B2 in carcinoma of the breast in Trinidadian women [abstract]
Rao, A; Mohammed, W. A; Ragoonanan, Celestine; Omo Igbinomwanhia, N. E.
Afiliação
  • Rao, A; University of the West Indies, St. Augustine, Trinidad and Tobago. Faculty of Medical Sciences
  • Mohammed, W. A; University of the West Indies, St. Augustine, Trinidad and Tobago. Faculty of Medical Sciences
  • Ragoonanan, Celestine; University of the West Indies, St. Augustine, Trinidad and Tobago. Faculty of Medical Sciences
  • Omo Igbinomwanhia, N. E; University of the West Indies, St. Augustine, Trinidad and Tobago. Faculty of Medical Sciences
West Indian med. j ; 50(Suppl 7): 37, Dec. 2001.
Artigo em Inglês | MedCarib | ID: med-17
Biblioteca responsável: JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
One hundred and three consecutive cases of breast cancer in Trinidadian women were evaluated for steroid receptor status and c-erb-B2 receptor along with clinicopathological data including age, race, tumour size, histological type and grade and lymph node status. The molecular markers were studied by immunohistochemistry (IHC) on parrafin sections. Tumour size of > 2cm was seen in 60 percent of the cases. Oestrogen receptor (ER), progesterone receptor (PR) and c-erb-B2 showed 54 percent, 46 percent and 63 percent positivity, respectively. There was no correlation between c-erb-B2 and steroid receptors. Forty-one percent (41 percent) of cases showed double negativity for steroid receptors (ER-/PR-). No correlation was found between the markers and clinicopathological data except for negative correlation with the tumour grade. The high percentage of c-erb-B2 positivity and the high proportion of steroid receptor negativity suggest a need for studies on adjuvant therapy. Integration of selected markers with conventional parameters could help define subgroups for treatment and prognosis. (AU)
Assuntos
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Coleções: Bases de dados internacionais Base de dados: MedCarib Assunto principal: Neoplasias da Mama / Receptores de Progesterona / Receptores de Esteroides / Receptores de Estrogênio / Receptor ErbB-2 Limite: Feminino / Humanos País/Região como assunto: Caribe Inglês / Trinidad e Tobago Idioma: Inglês Revista: West Indian med. j Ano de publicação: 2001 Tipo de documento: Artigo
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Coleções: Bases de dados internacionais Base de dados: MedCarib Assunto principal: Neoplasias da Mama / Receptores de Progesterona / Receptores de Esteroides / Receptores de Estrogênio / Receptor ErbB-2 Limite: Feminino / Humanos País/Região como assunto: Caribe Inglês / Trinidad e Tobago Idioma: Inglês Revista: West Indian med. j Ano de publicação: 2001 Tipo de documento: Artigo
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