Molecular epidemiology of multidrug resistant extended spectrum beta-lactamase producing Klebsiella pneumoniae at a Jamaican hospital, 2000 - 2004
BMC microbiology
; 10(27): [1-8], January 28, 2010. ilus, tab
Artigo
em Inglês
| MedCarib
| ID: med-17507
Biblioteca responsável:
TT5
ABSTRACT
BACKGROUND:
The accurate identification of a pathogen beyond the species level is critical in epidemiological studies and investigations of nosocomial outbreaks of infection. The clonal relatedness of 66 multidrug resistant (MDR) strains of extended spectrum beta-lactamase (ESBL) producing K. pneumoniae isolated from clinical specimens from hospitalized patients at a Jamaican hospital during a 5 year period were determined by pulsed field gel electrophoresis (PFGE).RESULTS:
A total 10 different ESBL producing K. pneumoniae genotypes designated Clones I-X were found. The most frequently occurring strains belonged to Clones I (21/66, 32%), II (15/66, 26%), III (13/66, 20%) and IV (8/66, 12%) which accounted for 86% (57/66) of ESBL producing K. pneumoniae strains over the 5 year period. The remaining 9 (14%) cases of ESBL producing K. pneumoniae were due to strains of Clones V-X. The 4 predominant clones persisted for several years in the hospital.CONCLUSIONS:
The clonal and temporal distribution of the MDR ESBL producing K. pneumoniae strains among clinical service areas did not suggest outbreaks of the organism during the period of study. Instead the molecular epidemiology of ESBL producing K. pneumoniae at this hospital was more representative of an endemic persistence of clones of the organism with limited dissemination from patient to patient. Further studies to investigate the factors which determine the emergence and persistence of MDR ESBL producing K. pneumoniae in Jamaican hospitals and their impact on clinical and economic outcomes at such institutions would be useful.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Doenças Negligenciadas
/
Zoonoses
Base de dados:
MedCarib
Assunto principal:
Resistência a Medicamentos
/
Epidemiologia Molecular
/
Jamaica
/
Klebsiella pneumoniae
Tipo de estudo:
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Humanos
País/Região como assunto:
Caribe Inglês
/
Jamaica
Idioma:
Inglês
Revista:
BMC microbiology
Tipo de documento:
Artigo
Instituição/País de afiliação:
Department of Microbiology/Jamaica