Hypoglycemic and Hepatoprotective activity of fermented fruit juice of Morinda citrifolia (Noni) in diabetic rats
Evidence-based complementary and alternative medicine : eCAM
; 2011: 5, 2011. grafilus
Artigo
em Inglês
| MedCarib
| ID: med-17584
Biblioteca responsável:
TT5
ABSTRACT
Morinda citrifolia is a medicinal plant used to treat diabetes and liver diseases. The fermented fruit juice of the M. Citrifolia (optical density = 1.25) was used to study the hypoglycemic and hepatoprotective properties in diabetes-induced rats. The rats were randomly distributed into 4 groups (control, diabetic experimental, diabetic standard, and diabetic untreated) of 6 each. Diabetes was induced by administering Streptozotocin (50 mg/kg body weight). Fasting blood glucose, body mass, liver tissue glycogen content, and the extent of liver degeneration were assessed. Diabetic experimental animals were treated with M. citrifolia juice (2 ml/kg, twice a day) and diabetic standard with reference hypoglycemic drug, glibenclamide orally for 20 days. Both the groups exhibited a significant reduction in blood glucose level of 150 mg/dl ñ15.88 and 125 mg/dl ñ3.89, respectively, as compared to diabetic untreated with FBS = 360.0 mg/dl ñ15.81, (P < .003). On 10th day of experiment, diabetic experimental animals exhibited a decrease in body mass (10.2 g, 5.11%) which increased significantly by the 20th day (6 g, 3.0%, P < .022). Histological study of liver tissue obtained from untreated diabetic animals revealed significant fatty degeneration as compared to other three groups. The data of this study proved the hypoglycemic and hepatoprotective activity of M. citrifolia.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Trinidad e Tobago
/
Morinda
/
Diabetes Mellitus
/
Hipoglicemiantes
Limite:
Animais
País/Região como assunto:
Caribe Inglês
/
Trinidad e Tobago
Idioma:
Inglês
Revista:
Evidence-based complementary and alternative medicine : eCAM
Ano de publicação:
2011
Tipo de documento:
Artigo
Instituição/País de afiliação:
The University of the West Indies/Trinidad and Tobago