Your browser doesn't support javascript.
loading
Sodium glucose Co transporter 2 (SGLT2) inhibitors: a new sword for the treatment of Type 2 Diabetes Mellitus
Rajesh, R. ; Naren, Patel; Vidyasagar, Sudha; Unnikrishnan, M. K. ; Pandey, Sureshwar; Varghese, Manju; Gang, Sagar.
Afiliação
  • Rajesh, R. ; Manipal University. Manipal College of Pharmaceutical Sciences. Department of Pharmacy Practice. Manipal. India
  • Naren, Patel; Manipal University. Manipal College of Pharmaceutical Sciences. Department of Pharmacy Practice. Manipal. India
  • Vidyasagar, Sudha; Manipal University. Kasturba Medical College. Department of Medicine. Karnataka. India
  • Unnikrishnan, M. K. ; Manipal University. Manipal College of Pharmaceutical Sciences. Department of Pharmacy Practice. Manipal. India
  • Pandey, Sureshwar; The University of the west Indies. Faculty of Medical Sciences. School of Pharmacy. St. Augustine. Trinidad and Tobago
  • Varghese, Manju; Manipal University. Manipal College of Pharmaceutical Sciences. Department of Pharmacy Practice. Manipal. India
  • Gang, Sagar; Manipal University. Manipal College of Pharmaceutical Sciences. Department of Pharmacy Practice. Manipal. India
Artigo em Inglês | MedCarib | ID: med-17639
Biblioteca responsável: TT5
ABSTRACT
The low affinity sodium glucose cotransporter (SGLT2) plays a major role in physiology of glucose re-absorption from proximal part of kidney. Almost all glucose excreted through glomerular filtration, is re-absorbed via SGLT2 until blood glucose level reaches to its threshold value for glucose excretion i.e. - 180mg/dl. Increasing the glucose excretion by inhibiting the SGLT2 is the novel approach for the treatment of diabetes. Safe and normal life of patients having familial renal glucosuria due to SLC5A2 gene mutation is accelerating the development of SGLT2 inhibitors. Weight loss and very low risk of hypoglycemia are the potential benefits of these inhibitors. There are number of molecules in this class under the stage of development.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MedCarib Assunto principal: Diabetes Mellitus Tipo 2 / Transportador 2 de Glucose-Sódio / Hipoglicemia / Insulina Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: International journal of pharma sciences and research Ano de publicação: 2010 Tipo de documento: Artigo Instituição/País de afiliação: Manipal University/India / The University of the west Indies/Trinidad and Tobago
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MedCarib Assunto principal: Diabetes Mellitus Tipo 2 / Transportador 2 de Glucose-Sódio / Hipoglicemia / Insulina Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: International journal of pharma sciences and research Ano de publicação: 2010 Tipo de documento: Artigo Instituição/País de afiliação: Manipal University/India / The University of the west Indies/Trinidad and Tobago
...