Delivery of antifungal agents using bioactive and nonbioactive bone cements
The annals of pharmacotherapy
; 43(10): 1606-1615, Oct. 2009. ilus, tab, graf
Artigo
em Inglês
| MedCarib
| ID: med-17669
Biblioteca responsável:
TT5
Localização: TT5; W1, AN6170
ABSTRACT
BACKGROUND:
Management of fungal osteomyelitis is prolonged and frequently unsuccessful. Antifungal-impregnated cement is sometimes used as adjunctive therapy.OBJECTIVE:
To examine the release of antifungals from biodegradable and nonbiodegradable cement carriers.METHODS:
In vitro methods were used to assess antifungal drug release and antifungal activity of impregnated cements commonly used as adjunctive treatment of osteomyelitis. Cements included thermoplastic, nonbioactive polymers (polymethylmethacrylate [PMMA]) or bioactive agents (hydroxyapatite [HAP], beta-tricalcium phosphate [beta-TCP]) and were formed into spheres (beads).RESULTS:
Amphotericin B provided consistent supernatant concentrations (release), between 1.75 and 2.0 microg/mL, over 110 days from all bone cements. Flucytosine and fluconazole were observed for 33-42 days before becoming undetectable from a nonbioactive sphere and 18-22 days from a bioactive sphere. Serum concentrations for micafungin, terbinafine, and anidulafungin impregnated into PMMA rapidly became undetectable, regardless of the matrix used. Investigational beta-TCP spheres prolonged release for fluconazole and micafungin, but had no effect on amphotericin B. Serum calcium concentrations decreased 60-80% in all HAP-impregnated drug sphere supernatants. Only amphotericin B-impregnated PMMA impacted supernatant calcium, decreasing concentrations by 50-60%. The antifungal-impregnated beads did not appear to be toxic to osteoblasts during 72 hours of exposure in tissue culture medium.CONCLUSIONS:
Elution characteristics of most antifungals from bone cement spheres are probably not optimal for treatment of deep-seated fungal infections if a similar phenomenon of antifungal release manifests in vivo. Ceramic nonabsorbable impregnated devices must be removed after their lifespan expires and may necessitate another surgical procedure that can increase surgical risk and cost. Bioactive osteoconductive materials may provide a surgical alternative to nonabsorbable matrices. However, there have been no controlled trials demonstrating improved therapeutic outcomes with local therapy and assessing whether biodegradable materials act as a new focus for infection.
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Osteoblastos
/
Trinidad e Tobago
/
Cimentos Ósseos
/
Durapatita
/
Polimetil Metacrilato
/
Antifúngicos
Limite:
Humanos
País/Região como assunto:
Caribe Inglês
/
Trinidad e Tobago
Idioma:
Inglês
Revista:
The annals of pharmacotherapy
Ano de publicação:
2009
Tipo de documento:
Artigo
Instituição/País de afiliação:
The University of the West Indies/Trinidad and Tobago
/
University of Alabama Medical Center/United States of America
/
University of Mississippi Medical Center/United States of America
/
University of Mississippi/United States of America