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Prediction of 10-year coronary heart disease risk in Caribbean type 2 diabetic patients using the UKPDS risk engine
Ezenwaka, C. E. ; Nwagbara, E. ; Seales, D. ; Okali, F. ; Hussaini, S. ; Raja, B. ; Jones-LeCointe, A. ; Sell, H. ; Avci, H. ; Eckel, J. .
Afiliação
  • Ezenwaka, C. E. ; The University of the West Indies. Faculty of Medical Sciences. Unit of Pathology & Microbiology. St. Augustine. Trinidad and Tobago
  • Nwagbara, E. ; Tobago Regional Health Authority. Scarborough. Trinidad and Tobago
  • Seales, D. ; The University of the West Indies. Faculty of Medical Sciences. Unit of Pathology & Microbiology. St. Augustine. Trinidad and Tobago
  • Okali, F. ; Tobago Regional Health Authority. Scarborough. Trinidad and Tobago
  • Hussaini, S. ; Tobago Regional Health Authority. Tobago. Trinidad and Tobago
  • Raja, B. ; Tobago Regional Health Authority. Scarborough. Trinidad and Tobago
  • Jones-LeCointe, A. ; The University of the West Indies. Faculty of Medical Sciences. Unit of Pathology & Microbiology. St. Augustine. Trinidad and Tobago
  • Sell, H. ; Institute of Clinical Biochemistry and Pathobiochemistry. German Diabetes Center. Dsseldorf. Germany
  • Avci, H. ; Institute of Clinical Biochemistry and Pathobiochemistry. German Diabetes Center. Dsseldorf. Germany
  • Eckel, J. ; Institute of Clinical Biochemistry and Pathobiochemistry. German Diabetes Center. Dsseldorf. Germany
International journal of cardiology ; 132(3): 348-353, Mar. 2009. tab
Artigo em Inglês | MedCarib | ID: med-17687
Biblioteca responsável: TT5
ABSTRACT

OBJECTIVE:

Primary prevention of Coronary Heart Disease (CHD) in diabetic patients should be based on absolute CHD risk calculation. This study was aimed to determine the levels of 10-year CHD risk in Caribbean type 2 diabetic patients using the diabetes specific United Kingdom Prospective Diabetes Study (UKPDS) risk engine calculator. SUBJECTS AND

METHODS:

Three hundred and twenty-five (106 males, 219 females) type 2 diabetic patients resident in two Caribbean Islands of Tobago and Trinidad met the UKPDS risk engine inclusion criteria. Records of their sex, age, ethnicity, smoking habit, diabetes duration, systolic blood pressure, total cholesterol, HDL-cholesterol and glycated haemoglobin were entered into the UKPDS risk engine calculator programme and the absolute 10-year CHD and stroke risk levels were computed. The 10-year CHD and stroke risks were statistically stratified into <15%, 15-30% and >30% CHD risk levels and differences between patients of African and Asian-Indian origin were compared.

RESULTS:

In comparison with patients in Tobago, type 2 diabetic patients in Trinidad, irrespective of gender, had higher proportion of 10-year CHD risk (10.4 vs. 23.6%, P<0.001) whereas the overall 10-year stroke risk prediction was higher in patients resident in Tobago (16.9 vs. 11.4%, P<0.001). Ethnicity-based analysis revealed that irrespective of gender, higher proportion of patients of Indian origin scored >30% of absolute 10-year CHD risk compared with patients of African descent (3.2 vs. 28.2%, P<0.001).

CONCLUSIONS:

The results of the study identified diabetic patients resident in Trinidad and patients of Indian origin as the most vulnerable groups for CHD. These groups of diabetic patients should have priority in primary or secondary prevention of coronary heart disease.
Assuntos
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Coleções: Bases de dados internacionais Contexto em Saúde: ODS3 - Saúde e Bem-Estar Problema de saúde: Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis Base de dados: MedCarib Assunto principal: Atenção Primária à Saúde / Trinidad e Tobago / Inibidores de Hidroximetilglutaril-CoA Redutases / Doença das Coronárias / Acidente Vascular Cerebral / Diabetes Mellitus Tipo 2 Tipo de estudo: Estudo de etiologia / Estudo prognóstico / Fatores de risco Limite: Idoso / Idoso, 80 anos ou mais / Feminino / Humanos / Masculino País/Região como assunto: Caribe Inglês / Trinidad e Tobago Idioma: Inglês Revista: International journal of cardiology Ano de publicação: 2009 Tipo de documento: Artigo Instituição/País de afiliação: Institute of Clinical Biochemistry and Pathobiochemistry/Germany / The University of the West Indies/Trinidad and Tobago / Tobago Regional Health Authority/Trinidad and Tobago
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Coleções: Bases de dados internacionais Contexto em Saúde: ODS3 - Saúde e Bem-Estar Problema de saúde: Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis Base de dados: MedCarib Assunto principal: Atenção Primária à Saúde / Trinidad e Tobago / Inibidores de Hidroximetilglutaril-CoA Redutases / Doença das Coronárias / Acidente Vascular Cerebral / Diabetes Mellitus Tipo 2 Tipo de estudo: Estudo de etiologia / Estudo prognóstico / Fatores de risco Limite: Idoso / Idoso, 80 anos ou mais / Feminino / Humanos / Masculino País/Região como assunto: Caribe Inglês / Trinidad e Tobago Idioma: Inglês Revista: International journal of cardiology Ano de publicação: 2009 Tipo de documento: Artigo Instituição/País de afiliação: Institute of Clinical Biochemistry and Pathobiochemistry/Germany / The University of the West Indies/Trinidad and Tobago / Tobago Regional Health Authority/Trinidad and Tobago
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