The effect of aromatic amino acid supplementation on a1- antirypsin synthesis in oedematous malnutrition
West Indian med. j
; 50(Suppl 5): 16, Nov. 2001. tab
Artigo
em Inglês
| MedCarib
| ID: med-201
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
OBJECTIVES:
We have previously demonstrated that infected children with oedematous protein energy malnutrition have an impaired acute phase response to infection. We hypothesize that this impaired response is due to a relative shortage of aromatic amino acids. We therefore sought to determine whether supplementation of the diet of infected oedematous malnourished children with aromatic amino acids (70 mg/kg/d phenylalanine, 80 mg/kg/d N-acetyltyrosine, 30 mg/kg/d tryptophan) would increase the rate of synthesis of acute phase proteins compared with an isonitrogenous diet supplemented with alanine.METHODS:
In oedematous malnourished children, a primed continuous infusion of 3H2-leucine was used to determine the in vivo synthesis rates of a1-antirypsin (a1-at), an acute phase protein, when they were infected (Study 1) and after clearing of infection (Study 2).RESULTS:
There was effect of aromatic amino acid supplementation on the rate of synthesis or concentration of a1-at.CONCLUSION:
Supplementation of the diet of oedematous malnourished children with aromatic amino acids did not enhance the immune response as determined by the in vivo synthesis of a1-at. (AU)
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Base de dados:
MedCarib
Assunto principal:
Deficiência de Proteína
/
Substituição de Aminoácidos
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
West Indian med. j
Ano de publicação:
2001
Tipo de documento:
Artigo