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Effect of aqueos neem leaf extract on blood pressure in conscious Wistar rats (a preliminary report)[abstract]
Obiefuna, Idongesit P; Young, Ronald E.
Afiliação
  • Obiefuna, Idongesit P; University of the West Indies, Mona, Jamaica. Department of Basic Medical Sciences
  • Young, Ronald E; University of the West Indies, Mona, Jamaica. Department of Basic Medical Sciences
West Indian med. j ; 50(Suppl 5): 15-6, Nov. 2001. tab
Artigo em Inglês | MedCarib | ID: med-202
Biblioteca responsável: JM3.1
Localização: JM3.1; R18.W4
ABSTRACT

OBJECTIVE:

This work investigates the effects of aqeous neem leaf extract on blood pressure (systolic, diastolic, and mean arterial pressure), heart rate and body weight in conscious Wistar rats.

METHODS:

The rats were divided into three groups of six. The first group received a daily intra-oesophageal bolus of 0.5 ml water. The 2nd and 3rd were given 20 mg/kg and 40 mg/kg body weight, respectively, of aqeous neem leef extract. Blood pressures and heart rate were measured using the LE 5002 Stroage Pressure meter (Letica Scientific Instruments). Body weight was also measured weekly for eight weeks. Statistical analysis was carried out using SPSS.

RESULTS:

Blood pressure, heart rate and body rate were not statistically different between the three groups on day 1. By week 8, the diastolic and mean arterial pressures wre significantly lower (p<0.0001) in the two neem-treated groups than in the controls. There was also no significant difference in weight between the groups.

CONCLUSION:

The results show that administration of o 20 mg/kg-body weight of aqeuous neem leaf extract reduces diastoloc and mena arterial blood pressures in conscious rats (AU)
Assuntos
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Coleções: Bases de dados internacionais Base de dados: MedCarib Assunto principal: Peso Corporal / Folhas de Planta / Pressão Arterial / Frequência Cardíaca Idioma: Inglês Revista: West Indian med. j Ano de publicação: 2001 Tipo de documento: Artigo
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Coleções: Bases de dados internacionais Base de dados: MedCarib Assunto principal: Peso Corporal / Folhas de Planta / Pressão Arterial / Frequência Cardíaca Idioma: Inglês Revista: West Indian med. j Ano de publicação: 2001 Tipo de documento: Artigo
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