A clinico-pathological study of Cushing's syndrome at the University Hospital of the West Indies and a review of literature
West Indian med. j
; 50(1): 55-61, Mar. 2001. ilus, tab, gra
Artigo
em Inglês
| MedCarib
| ID: med-318
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
Cushing's syndrome is an uncommon but important disease. Twenty-one confirmed cases of spontaneous Cuching's syndrome were documented at the University Hospital of the West Indies over a 21-year period. They were predominantly young females (FM ratio of 174; mean age 25 years and three months). The commonest presenting symptoms were amenorrhoea (41 percent) and obesity (19 percent). Common clinical features were cushingnoid features (95 percent), hypertension (76 percent) and hirsutism (82 percent). Twenty-nine per cent had frank hyperglycaemia. Cushing's syndrome was due to Cushing's disease in 10 cases, adrenal adenoma in 3 and adrenal carcinoma in 2 cases. In 4 cases with presumed adrenal hyperplasia, the histology was either unavailable or was not consistent with the diagnosis. Two cases appear now to have had ectopic ACTH syndrome. Adrenalectomy was the commonest treatment offered. There were no intra-operative or post-operative deaths but recurrence was common after subtotal adrenalectomy in Cushing's disease. Twenty-seven per cent of the patients developed Nelson's syndrome, which was fatal in 50 per cent. Long-term hormone replacement therapy was unnecessary after surgery for adrenal adenomas. Treatment of Cushing's syndrome was well tolerated by the patients. (AU)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Síndrome de Cushing
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
Limite:
Adolescente
/
Adulto
/
Criança
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Caribe
Idioma:
Inglês
Revista:
West Indian med. j
Ano de publicação:
2001
Tipo de documento:
Artigo