Your browser doesn't support javascript.
loading
Antibiotic susceptibility of clostridium difficile isolates from adult patients at two Jamaican hospitals. Clinical and epidemiological implications
Heslop, O. D; King, S. Dorothy; Levett, Paul N; Barton, Everard N; Wynter, Juliet.
Afiliação
  • Heslop, O. D; University of the West Indies, Mona, Jamaica. Department of Microbiology. ohes@cwjamaica.com
  • King, S. Dorothy; University of the West Indies, Mona, Jamaica. Department of Microbiology
  • Levett, Paul N; University of the West Indies, Mona, Jamaica. Department of Microbiology
  • Barton, Everard N; University of the West Indies, Mona, Jamaica. Department of Medicine
  • Wynter, Juliet; University of the West Indies, Mona, Jamaica. Department of Medicine
West Indian med. j ; 50(1): 50-4, Mar. 2001. tab
Artigo em Inglês | MedCarib | ID: med-319
Biblioteca responsável: JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
The susceptibility of 39 toxin producing Clostridium difficile isolates from stools of hospitalized patients was determined, by disc diffusion, to six antibiotics. All but one isolate (toxin A negative) produced toxin A and Toxin B. A wide variation in susceptibility to clindamycin, tetracycline and chloramphenicol was noted. Erythromycin and cotrimoxazole showed a clear-cut discrimination in resistance and susceptibility, while all isolates were sensitive to vancomycin. Erythromycin sensitive isolates demonstrates a significant association with diarrhoea (60.9 percent, 14/23, p<0.001). These strains were predominantly found at the University Hospital of the West Indies (UHWI, 94.1 percent, 16/17). Strains resistant to erythromycin and clindamycin together were commonly found at the National Chest Hospital (NCH, 68.2 percent, 15/22). All erythromycin sensitive strains found at the NCH were from patients transfered to that hospital. These findings suggest that there is a common strain of C difficile (erythrmycin resistant) at the NCH different from that found at the UHWI; the resistant pattern seen with isolates from the NCH was typical of toxigenic serogroup C strain and could be typed by the disc diffusion method. Patients at the NCH who were colonized with either of the two strains of C difficile were likely to get diarrhoea, once there suppression of the normal microflora by antibiotics and colonic over growth with C difficile. (AU)
Assuntos
Buscar no Google
Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Negligenciadas Problema de saúde: Diarreia / Doenças Negligenciadas Base de dados: MedCarib Assunto principal: Enterocolite Pseudomembranosa / Testes de Sensibilidade Microbiana / Clostridioides difficile / Diarreia / Antibacterianos Limite: Adolescente / Adulto / Idoso / Idoso, 80 anos ou mais / Feminino / Humanos / Masculino País/Região como assunto: Caribe Inglês / Jamaica Idioma: Inglês Revista: West Indian med. j Ano de publicação: 2001 Tipo de documento: Artigo
Buscar no Google
Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Negligenciadas Problema de saúde: Diarreia / Doenças Negligenciadas Base de dados: MedCarib Assunto principal: Enterocolite Pseudomembranosa / Testes de Sensibilidade Microbiana / Clostridioides difficile / Diarreia / Antibacterianos Limite: Adolescente / Adulto / Idoso / Idoso, 80 anos ou mais / Feminino / Humanos / Masculino País/Região como assunto: Caribe Inglês / Jamaica Idioma: Inglês Revista: West Indian med. j Ano de publicação: 2001 Tipo de documento: Artigo
...