The red cell distribution width in sickle cell disease: is it of clinical value?
Clin Lab Haematol
; 13: 229-37, 1991. tab, gra
Artigo
em Inglês
| MedCarib
| ID: med-3596
Biblioteca responsável:
JM3.1
Localização: JM3.1; Reprint Collection
ABSTRACT
The red cell distribution width (RDW) has been studied during the clinical steady state in 1121 patients with homozygous sickle cell (SS) disease, 344 with sickle cell-haemoglobin C (SC) disease, 68 with sickle cell-beta+ thalassaemia, 49 with cell beta§ thalassaemia and in 130 control subjects with a normal (AA) genotype. The mean RDW was moderately increased in Sbeta+ thalassaemia and SC disease and markedly increased in Sbeta§ thalassaemia and SS disease. In SS, SC and Sbeta§ thalassaemia genotypes, lower RDW values occurred in females and with alpha thalassaemia. The RDW correlated negatively with total haemoglobin, mean cell haemoglobin concentration, mean cell volume and fetal haemoglobin (HbF) and positively with reticulocyte count in SS disease. A low RDW was associated with higher weight and less frequent dactylitis, painful crisis, acute chest syndrome, acute splenic sequestration and hospital admissions. A low RDW in SS disease is consistent with a high total haemoglobin, high HbF, low reticulocyte count, alpha thalassaemia and a more mild clinical course. (AU)
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Base de dados:
MedCarib
Assunto principal:
Traço Falciforme
/
Índices de Eritrócitos
/
Eritrócitos Anormais
/
Anemia Falciforme
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Fatores de risco
Aspecto:
Preferência do paciente
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Inglês
Revista:
Clin Lab Haematol
Ano de publicação:
1991
Tipo de documento:
Artigo