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The effects of chronic S-nitrosoglutathoine adminstration on glucose tolerance in dog animal model
McGrowder, Donavan; Ragoobirsingh, Dalip; Dasgupta, Tara P.
Afiliação
  • McGrowder, Donavan; University of the West Indies, Mona, Jamaica. Department of Basic Medical Sciences
  • Ragoobirsingh, Dalip; University of the West Indies, Mona, Jamaica. Department of Basic Medical Sciences
  • Dasgupta, Tara P; University of the West Indies, Mona, Jamaica. Departemnt of Chemistry
West Indian med. j ; 50(suppl. 1): 55, Mar. 1-4, 2001.
Artigo em Inglês | MedCarib | ID: med-420
Biblioteca responsável: JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
The nitric oxide donor S-nitrosoglutathione (GSNO) has been used to prevent platelet activation in patients with severe pre-eclampsia. The study assesses the chronic administration of GSNO on glucose metabolism in the dog animal model. GSNO (10 mg/kg) was administered intravenously for 14 days and the blood glucose concentration was determined by the glucose oxidase method. Oral glucose tolerance tests revealed an impaired glucose tolerance in the GSNO-treated dogs as reflected by elevated postprandial blood glucose concentrations at the 1.0 hour to 2.5 hour time interval (p < 0.05). The elevated blood glucose concentration was associated with a statistically significant decrease in plasma insulin concentration. The plasma insulin concentration at 1.0 hour in captopril-treated controls was 41.00 uIU/ml compared with 27.33 uIU/ml in GSNO-treated dogs (p < 0.05). In contrast, the plasma glucagon concentration was enhanced by the chronic adminstration of GSNO, as confirmed by a concentration of 75.00 ñ 6.06 pg/ml in GSNO-treated dogs compared with 49.50 ñ 4.64 pg/ml in captopril-treated controls at the 1.0 hour time interval. Linear regression analysis of the data revealed a highly significant and positive correlation between the blood glucose concentration and the plasma glucagon concentration (r = 0.739, p < 0.01). Similarly, a positive correlation existed between the blood glucose concentration and the plasma insulin concentration (r = 0.513, p = 0.307). We conclude that chronic in vivo adminstration of GSNO impairs the parameters of carbohydrate metabolism. Patients who are on protracted treatment with GSNO could be risk for the development of diabetes mellitus.(Au)
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Coleções: Bases de dados internacionais Base de dados: MedCarib Assunto principal: Ativação Plaquetária / Doadores de Óxido Nítrico / Glucose Limite: Animais Idioma: Inglês Revista: West Indian med. j Ano de publicação: 2001 Tipo de documento: Artigo