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Control of renal cortex ammoniagenesis and its relationship to renal cortex gluconeogenesis
Biochim Biophys Acta ; 362(1): 83-91, 1974.
Artigo em Inglês | MedCarib | ID: med-5058
Biblioteca responsável: JM3.1
Localização: JM9.1; QP501.B55
ABSTRACT
The metabolism of glutamate by kidney cortical slices from normal and acutely acidotic rats and the effect of acidosis in vitro on the metabolism of these two substrates has been investigated. The effects of calcium on all these processes was also studied. Kidney cortical slices from acutely acidotic rats utilized more glutamine and formed more ammonia, glucose and glutamate than slices from rats. Increased glutamine utilization and ammoniagenesis by cortical slices from acidotic rats was not detected when Ca2+ was omitted from the medium, although glucose formation was still enhanced and glutamate formation decreased. With in vitro acidosis there was no change in glutamine uptake in the presence or absence of calcium but with calcium, ammonia production fell. Although there was no change in glutamate uptake by cortical slices from acidotic rats, there was an increase in ammoniagenesis and gluconeogenesis with or without calcium. With in vitro acidosis the only significant changes were an increase in ammoniagenesis and gluconeogenesis in the absence of calcium. The results show that ammoniagenesis from glutamine is controled by a rate-limiting step distinct from that which controls deamination of glutamate and gluconeogenesis from glutamine and glutamate. Possible control points and the interrelationship between ammoniagenesis and gluconeogenesis are discussed (AU)
Assuntos
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Coleções: Bases de dados internacionais Base de dados: MedCarib Assunto principal: Gluconeogênese / Córtex Renal Limite: Animais Idioma: Inglês Revista: Biochim Biophys Acta Ano de publicação: 1974 Tipo de documento: Artigo
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Coleções: Bases de dados internacionais Base de dados: MedCarib Assunto principal: Gluconeogênese / Córtex Renal Limite: Animais Idioma: Inglês Revista: Biochim Biophys Acta Ano de publicação: 1974 Tipo de documento: Artigo
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