Treatment of patients infected with Strongyloides stercoralis using ivermectin: assessment of efficacy and safety - abstract
West Indian med. j
; 44(Suppl. 3): 10-1, Nov. 1995.
Artigo
em Inglês
| MedCarib
| ID: med-5086
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
Infections with Strongyloides stercoralis are often refractory to thiabendazole therapy in certain patients. Ivermectin is being used increasingly for treatment of uncomplicated infections; however, possible immunopathological changes associated with drug-induced release of antigens as observed with use of the drug in filariasis has not been studied in strongyloidiasis. In this study we used the enzyme linked immunosorbant assay (ELISA) technique to examine the profiles of S. stercoralis-specific IgG4, IgE and IgA against saline soluble filariform extracts in 8 patients treated for the parasite. All patients were found to be negative for the parasite by stool examination following treatment. Isotype levels fell in concert following treatment although there was considerable heterogeneity among patients. Levels remained low following treatment response but were still measurable for up to eighteen months post-treatment. There appeared to be no rapid release of parasite antigens following treatment. One patient exhibited a transient increase in levels of IgA after which there was a decline in this and all other isotypes. The single patient with proven chronic infection and a history of gastrointestinal symptoms exhibited almost ablated IgG1, IgE and IgA responses prior to treatment but had a significant IgG4 response which remained high following treatment. The reduction in antibody levels post-treatment may be used as confirmation of parasitological cure. The study showed that there was no rapid release of S. stercoralis antigens as seen in filarial infections and that Ivermectin is safe and effective against the parasite (AU)
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Coleções:
Bases de dados internacionais
Contexto em Saúde:
Doenças Negligenciadas
/
ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Problema de saúde:
Helmintíase
/
Doenças Negligenciadas
/
Estrongiloidíase
Base de dados:
MedCarib
Assunto principal:
Ivermectina
/
Strongyloides stercoralis
Limite:
Humanos
Idioma:
Inglês
Revista:
West Indian med. j
Ano de publicação:
1995
Tipo de documento:
Artigo
/
Congresso e conferência