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HTLV-1 infection - a risk factor for severe strongyloidiasis? - abstract
West Indian med. j ; 42(Suppl. 1): 32, Apr. 1993.
Artigo em Inglês | MedCarib | ID: med-5141
Biblioteca responsável: JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
Epidemiological associations of Strongyloides stercoralis and Human T-Lymphotropic Virus Type-1 (HTLV-1) were investigated at eleven (11) foci endemic for strongyloidiasis in Jamaica. Each focus was identified on the basis of residency of a parasitologically-proved case of strongyloidiasis who presented at the University Hospital. Three hundred and twelve (312) persons were contacted, and blood and stool samples were collected for HTLV-1 and S. stercoralis serology and S. stercoralis coproculture, respectively. Overall compliance was 66.6 per cent. The prevalence of S. stercoralis in the pooled foci was 8.2 per cent including and 4.0 per cent excluding the hospital presenters, and for HTLV-1 it was 11.1 per cent and 8.1 per cent. Seroprevalence of S. stercoralis infection was 30 per cent and 26.8 per cent with and without the clinical cases, respectively. The prevalence of each infection was correlated with the age of the host (Spearman Rank Correlation, p<0.001). HTLV-1 was clustered in S. stercoralis larval shedders (58.8 per cent, n=17) compared with non-shedders (8.9 per cent, n=45) (Fisher's exact test, p<0.001), but particularly so among clinical cases 7 of whom (n=9) had HTLV-1 antibodies. The association was explained on the basis of age-related total serum IgE levels in HTLV-1/S. stercoralis infection cases. Individuals uninfected by S. stercoralis displayed a tendency for decreased IgE levels with age. This especially so in HTLV-1 carriers (ANCOVA age * HTLV-1 interaction term t = 3.176, p<0.002). In marked contrast, S. stercoralis seropositive individuals had significantly elevated IgE titres in older persons compared with seronegative controls (ANCOVA age * S. stercoralis interaction term t = 3.733, p<0.001). In persons seropositive for both HTLV-1 and S. stercoralis, however, the elevation of IgE levels previously observed in S. stercoralis positive individuals was completely subsumed by the negative influence of HTLV-1. It is suggested that impairment of host immunity by HTLV-1, and/or S. stercoralis in the presence of HTLV-1, exacerbates strongyloidiasis resulting in increased frequency of both larval shedding and parasite disease. Effect of S. stercoralis (S) and HTLV-1 (H) infection status on the host age/serum IgE association. This figure is designed to illustrate general trends; ungrouped data were used in statistical analyses (AU)
Assuntos
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Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Negligenciadas / ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis Problema de saúde: Helmintíase / Doenças Negligenciadas / Estrongiloidíase Base de dados: MedCarib Assunto principal: Estrongiloidíase / Infecções por HTLV-I Tipo de estudo: Estudo de etiologia / Estudo prognóstico / Fatores de risco Limite: Humanos País/Região como assunto: Caribe Inglês / Jamaica Idioma: Inglês Revista: West Indian med. j Ano de publicação: 1993 Tipo de documento: Artigo / Congresso e conferência
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Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Negligenciadas / ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis Problema de saúde: Helmintíase / Doenças Negligenciadas / Estrongiloidíase Base de dados: MedCarib Assunto principal: Estrongiloidíase / Infecções por HTLV-I Tipo de estudo: Estudo de etiologia / Estudo prognóstico / Fatores de risco Limite: Humanos País/Região como assunto: Caribe Inglês / Jamaica Idioma: Inglês Revista: West Indian med. j Ano de publicação: 1993 Tipo de documento: Artigo / Congresso e conferência
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