The immunophenotyping of non-hodgkin's lymphoma in formalin-fixed paraffin-embedded tissue - abstract
West Indian med. j
; 39(Suppl. 1): 65-6, Apr. 1990.
Artigo
em Inglês
| MedCarib
| ID: med-5241
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
In this study, we have retrospectively determined the immunophenotype of forty-five cases of non-Hodgkin's lymphoma (HNL) diagnosed in the Department of Pathology at the University Hospital of the West Indies (UHWI) between 1984 and 1986. We used an immunoalkaline phosphatase technique with a panel of monoclonal antibodies reactive against T-cells (UCHL 1; MT 1), B cells (L 26; 4KB5; LN 2) and macrophages (Ber.H2). We found that this panel could accurately identify T-cell lymphomas and B cell lymphomas in formalin-fixed paraffin-embedded tissues. Of forty-five cases, twenty-six were of T-cell lineage and twelve were of B-cell lineage. Sixteen of the T-cell lymphomas were human T-cell leukemia-lymphoma virus type 1 (HTLV-1) positive and showed the additional clinical and pathological features of adult T-cell leukemia/lymphoma (ATL). The HTLV-1 negative cases were neither morphologically nor immunologically different from the HTLV-1 positive patients. None of the B cell lymphomas were HTLV-1 positive. The results lend further support to the finding that NHL in Jamaican patients is predominantly of T cell origin and associated with human T cell lymphotropic virus, type 1 (AU)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Linfoma não Hodgkin
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Adulto
/
Humanos
País/Região como assunto:
Caribe Inglês
/
Jamaica
Idioma:
Inglês
Revista:
West Indian med. j
Ano de publicação:
1990
Tipo de documento:
Artigo
/
Congresso e conferência