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Coincidental HTLV-I infection influences outcome of treatment of strongyloidiasis - abstract
West Indian med. j ; 38(Suppl. 1): 36, April 1989.
Artigo em Inglês | MedCarib | ID: med-5680
Biblioteca responsável: JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
It is uncertain whether HTLV-I infection and Strongyloidiasis are related other than by chance. A consecutive series of Jamaican patients and controls have been analysed retrospectively for anti-Strongyloides and HTLV-1 antibodies to determine whether either influences the outcome of anti-helminthic therapy. Twenty-seven Jamaicans (16 M, 11F) mean age 50.2 years (range 16-85), who were found to have Strongyloides stercoralis infection were studied at the University Hospital of the West Indies. At the same time, a parasite-negative group of 13 patients (6M, 7F) of mean age 37.6 years, (range 23-53), with minor or no gastrointestinal disease served as controls. Pretreatment blood samples were taken from the Strongyloides group and controls. Serum was subsequently tested for IgG antibodies to filariform Strongyloides stercoralis larval antigens by ELISA and to HTLV-1 by ELISA and Western Blot. Outcome of the treatment of Strongyloidiasis with thiabendazole (25 -mg/kg b.d. orally for 10 days was determined at 2 months. Strongyloides reciprocal antibody titre was considerably higher in patients than controls, mean 870 vs 167; median 1,024 vs 8 (p<0.001). The sensitivity of the antibody test was 93 percent, but the specificity was 69 percent at best. There was no correlation with the anti-Strongyloides antibody titre and outcome with anti-helminthic therapy. HTLV-1 antibodies were found only in the Strongyloides patients, 12 of 27 (44 percent); antibody titres were high and positive with both test used only one patient was known beforehand to have a disease associated with HTLV-1 infection. Of those 12 with HTLV-1 antibodies, 3 (25 percent) were cured, 7 still had the infection at 2 months, a further 2 had died or defaulted from follow-up. Of the 15 patients without HTLV-1 antibodies, 9 (60 percent) were cured, 3 still had the infection and 3 had died or defaulted. By chi-square analysis, the difference is significant whether one includes all the deaths and defaulters on an intention-to-treat basis or just those who were available at 2 months post-therapy. However, since none of the deaths were related to Stongyloidiasis or HTLV-1 injection, it is probably justifiable to exclude the deaths from the computation. These results show that the association of Strongyloidiasis and HTLV-1 is more than chance clustering. Not only is the prevalence of HTLV-1 antibodies far higher in the patients with Strongyloidiasis than in the normal Jamaican population, but that concurrent asymptomatic HTLV-1 infection interferes with anti-helminthic treatment (AU)
Assuntos
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Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Negligenciadas / ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis Problema de saúde: Helmintíase / Doenças Negligenciadas / Zoonoses / Estrongiloidíase Base de dados: MedCarib Assunto principal: Estrongiloidíase / Infecções por HTLV-I Tipo de estudo: Fatores de risco Limite: Adolescente / Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: West Indian med. j Ano de publicação: 1989 Tipo de documento: Artigo / Congresso e conferência
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Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Negligenciadas / ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis Problema de saúde: Helmintíase / Doenças Negligenciadas / Zoonoses / Estrongiloidíase Base de dados: MedCarib Assunto principal: Estrongiloidíase / Infecções por HTLV-I Tipo de estudo: Fatores de risco Limite: Adolescente / Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: West Indian med. j Ano de publicação: 1989 Tipo de documento: Artigo / Congresso e conferência
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