Your browser doesn't support javascript.
loading
The first report of familial adult T-cell leukaemia lymphoma in the United Kingdom
Br J Haematol ; 89(3): 615, Mar. 1995.
Artigo em Inglês | MedCarib | ID: med-5892
Biblioteca responsável: JM3.1
Localização: JM3.1; RB145.A1B7
ABSTRACT
We describe two siblings who developed adult T-cell leukaemia lymphoma (ATLL) within 4 years. Both were black of Afro-Caribbean extraction, but one had been born in the United Kingdom and had visited the Caribbean only once. Both patients were HTLV-1 seropositive, as was their mother; their father and brother were negative. The older siblings had the lymphoma form of ATLL, whilst the younger had chronic ATLL. The former was unresponsive to chemotherapy and died of progressive disease; the latter chemotherapy and died of progressive disease; the latter experienced transient responses to various treatments and is alive 5 years after presentation. Immunophenotyping showed a CD4+, CD25+ phenotype; Southern blot demonstrated a monoclonal integration of HTLV-I in the tissues involved. This report, of the first familial ATLL in the U.K., supports the suggestion of transmission of HTLV-I from mother to child and documents and the development of ATLL in second-generation Caribbean immigrants (AU)
Assuntos
Buscar no Google
Coleções: Bases de dados internacionais Base de dados: MedCarib Assunto principal: Leucemia-Linfoma de Células T do Adulto / Transmissão Vertical de Doenças Infecciosas Limite: Feminino / Humanos / Masculino País/Região como assunto: Caribe Inglês / Trinidad e Tobago Idioma: Inglês Revista: Br J Haematol Ano de publicação: 1995 Tipo de documento: Artigo
Buscar no Google
Coleções: Bases de dados internacionais Base de dados: MedCarib Assunto principal: Leucemia-Linfoma de Células T do Adulto / Transmissão Vertical de Doenças Infecciosas Limite: Feminino / Humanos / Masculino País/Região como assunto: Caribe Inglês / Trinidad e Tobago Idioma: Inglês Revista: Br J Haematol Ano de publicação: 1995 Tipo de documento: Artigo
...