Serological tests for lyme disease in patients with tropical spastic paraparesis and healthy Jamaicans
Trop Geogr Med
; 46(5): 329-30, 1994.
Artigo
em Inglês
| MedCarib
| ID: med-6350
Biblioteca responsável:
JM3.1
Localização: JM3.1; RC960.T7
ABSTRACT
The significance of reactive serlogical tests for lyme disease in patients with tropical spastic paraparesis (TSP) was assessed by examining serum samples from 128 of these patients and 200 healthy Jamaicans by lyme indirect immunofluorescent antibody (IFA), enzyme immuno-assay (EIA) and western blot analyses. Sera were also examined in serological tests for syphilis (STS), an unabsorbed fluorescent treponemal antibody test and leptospira microagglutination test. The prevalence of positive Lyme IFA and EIA results did not differ significantly between sera from TSP patients (12.5 percent and healthy controls (10.0 percent). Western blot analyses showed that the positive lyme IFA and EIA results observed in this study were due to false positive reactions. Seventy-five per cent of lyme IFA/EIS positive sera from TSP patients had treponemal antibodies. Eighty per cent of those from healthy controls were negative in standard STS but 85 percent were positive when tested in an unabsorbed fluorescent treponemal antibody (FTA). These data indicate that reactive serological tests for lyme disease in Jamaican TSP patients and healthy Jamaicans are false positive reactions due to cross-reactivity with other spirochaetes, notably treponema pallidum and non pathogenic treponemes (AU)
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Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Base de dados:
MedCarib
Assunto principal:
Sorologia
/
Doença de Lyme
/
Paraparesia Espástica Tropical
Tipo de estudo:
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Caribe Inglês
/
Jamaica
Idioma:
Inglês
Revista:
Trop Geogr Med
Ano de publicação:
1994
Tipo de documento:
Artigo