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Chromosome studies in primary amenorrhoea - abstract
West Indian med. j ; 18(4): 247, Dec. 1969.
Artigo em Inglês | MedCarib | ID: med-6390
Biblioteca responsável: JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
Between April, 1964 and December, 1968, we have performed buccal smears and chromosome studies on a total of 46 patients with primary and secondary amenorrhoea and oligomenorrhoea.

RESULTS:

(1) Secondary amenorrhoea - 4 cases. All had normal chromosomes, all were over 62" in height, with normal build and sexual development. (2) Oligomenorrhoea - 10 cases. Five had moderate degrees of virilisation. One of these had chromosomal findings suggestive of XX/XO mosaicism. Five patients had normal secondary sex characteristics and had normal chromosomes. All 10 patients were 60" or more in height. (3) Primary Amenorrhoea 32 patients. These can be divided into 3 clinical groups. (a) Those with sexual infantilism - 21 cases. Of these, 10 showed sex chromosomal abnormalities. Six of these were less than 60" and hibited other features suggestive of gonadal dysgenesis. Of the 11 with normal chromosomes, 4 were under 57" in height and 3 of these were mentally retarded. (a) Those with sexual infantilism - 21 cases. Of these, 10 showed sex chromosomal abnormalities. Six of these were less than 60" and exhibited other features suggestive of gonadal dysgensis. Of the 11 with normal chromosomes, 4 were under 57" in height and 3 of these were mentally retarded. (b) Patients with virilisation - 7 cases. All these patients were small in size, around 60 to 63 inches in height, but were not dwarfed. Two were found to have congenital adrenal hyperplasia. The others have not all been fully investigated for this condition. (c) Normal secondary sex characteristics - 4 cases. Three had normal chromosomes. One patient had 46xx but a small line showed a small chromosomal fragment. Laparotomy revealed normal ovaries. Two other patients in this group had atresia of the vagina and cervix.

CONCLUSION:

34 percent of patients with primary amenorrhoea have chromosmal abnormalities. Chromosome studies are, therefore, indicated in all such patients and probably some with oligomenorrhoea. All patients except those found to have congenital adrenal hyperplasia should have either full genital tract examinations or gonadal exploration, the former being indicated if there are normal secondary sex characteristics, and the latter if there is infantilism or virilisation not explained by congenital adrenal hyperplasia (AU)
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Coleções: Bases de dados internacionais Base de dados: MedCarib Assunto principal: Cromossomos / Amenorreia Limite: Feminino / Humanos Idioma: Inglês Revista: West Indian med. j Ano de publicação: 1969 Tipo de documento: Artigo / Congresso e conferência